RECENT PUBLICATIONS 2004-2009

Eng C, Leone G, Orloff MS, Ostrowski MC.

Genomic alterations in tumor stroma.

Cancer Res. 2009 Sep 1;69(17):6759-64. Epub 2009 Aug 25.
PMID: 19706759

Pan F, Yu H, Dang EV, Barbi J, Pan X, Grosso JF, Jinasena D, Sharma SM, McCadden EM, Getnet D, Drake CG, Liu JO, Ostrowski MC, Pardoll DM.

Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells.

Science. 2009 Aug 28;325(5944):1142-6. Epub 2009 Aug 20.
PMID: 19696312

Kampfrath T, Deiuliis JA, Moffatt-Bruce SD, Anderson J, Sun Q, Wood K, Ostrowski MC, Rajagopalan S.

A mouse model of yellow fluorescent protein (YFP) expression in hematopoietic cells to assess leukocyte-endothelial interactions in the microcirculation.

Microvasc Res. 2009 Aug 12. [Epub ahead of print]
PMID: 19682464

Wei G, Srinivasan R, Cantemir-Stone CZ, Sharma SM, Santhanam R, Weinstein M, Muthusamy N, Man AK, Oshima RG, Leone G, Ostrowski MC.

Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis.

Blood. 2009 Jul 30;114(5):1123-30. Epub 2009 May 1.
PMID: 19411629

Sharma SM, Sif S, Ostrowski MC, Sankar U.

Defective co-activator recruitment in osteoclasts from microphthalmia-oak ridge mutant mice.

J Cell Physiol. 2009 Jul;220(1):230-7.
PMID: 19288495

Sun Q, Yue P, Deiuliis JA, Lumeng CN, Kampfrath T, Mikolaj MB, Cai Y, Ostrowski MC, Lu B, Parthasarathy S, Brook RD, Moffatt-Bruce SD, Chen LC, Rajagopalan S.

Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity.

Circulation. 2009 Feb 3;119(4):538-46. Epub 2009 Jan 19.
PMID: 19153269

Sun Y, Ishibashi M, Seimon T, Lee M, Sharma SM, Fitzgerald KA, Samokhin AO, Wang Y, Sayers S, Aikawa M, Jerome WG, Ostrowski MC, Bromme D, Libby P, Tabas IA, Welch CL, Tall AR.

Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K.

Circ Res. 2009 Feb 27;104(4):455-65. Epub 2009 Jan 2.
PMID: 19122179

Joshi T, Ganesan LP, Cheney C, Ostrowski MC, Muthusamy N, Byrd J, Tridandapani S.

The PtdIns 3-kinase/Akt pathway regulates macrophage-mediated ADCC against B cell lymphoma.

PLoS One. 2009;4(1):e4208. Epub 2009 Jan 16.
PMID: 19148288

Lin HJ, Zuo T, Lin CH, Kuo CT, Liyanarachchi S, Sun S, Shen R, Deatherage DE, Potter D, Asamoto L, Lin S, Yan PS, Cheng AL, Ostrowski MC, Huang TH.

Breast cancer-associated fibroblasts confer AKT1-mediated epigenetic silencing of Cystatin M in epithelial cells.

Cancer Res. 2008 Dec 15;68(24):10257-66.
PMID: 19074894

Aliprantis AO, Ueki Y, Sulyanto R, Park A, Sigrist KS, Sharma SM, Ostrowski MC, Olsen BR, Glimcher LH.

NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism.

J Clin Invest. 2008 Nov;118(11):3775-89. Epub 2008 Oct 9.
PMID: 18846253

Hou Y, Li F, Karin M, Ostrowski MC.

Analysis of the IKKbeta/NF-kappaB signaling pathway during embryonic angiogenesis.

Dev Dyn. 2008 Oct;237(10):2926-35.
PMID: 18816823

Hume DA, Sasmono T, Himes SR, Sharma SM, Bronisz A, Constantin M, Ostrowski MC, Ross IL.

The Ewing sarcoma protein (EWS) binds directly to the proximal elements of the macrophage-specific promoter of the CSF-1 receptor (csf1r) gene.

J Immunol. 2008 May 15;180(10):6733-42.
PMID: 18453593

Crotti TN, Sharma SM, Fleming JD, Flannery MR, Ostrowski MC, Goldring SR, McHugh KP.

PU.1 and NFATc1 mediate osteoclastic induction of the mouse beta3 integrin promoter.

J Cell Physiol. 2008 Jun;215(3):636-44.
PMID: 18288635

Trimboli AJ, Fukino K, de Bruin A, Wei G, Shen L, Tanner SM, Creasap N, Rosol TJ, Robinson ML, Eng C, Ostrowski MC, Leone G.

Direct evidence for epithelial-mesenchymal transitions in breast cancer.

Cancer Res. 2008 Feb 1;68(3):937-45.
PMID: 18245497

Sussan TE, Yang A, Li F, Ostrowski MC, Reeves RH.

Trisomy represses Apc(Min)-mediated tumours in mouse models of Down's syndrome.

Nature. 2008 Jan 3;451(7174):73-5.
PMID: 18172498 [PubMed - indexed for MEDLINE]

Opavsky R, Wang SH, Trikha P, Raval A, Huang Y, Wu YZ, Rodriguez B, Keller B, Liyanarachchi S, Wei G, Davuluri RV, Weinstein M, Felsher D, Ostrowski M, Leone G, Plass C.

CpG island methylation in a mouse model of lymphoma is driven by the genetic configuration of tumor cells.

PLoS Genet. 2007 Sep;3(9):1757-69. Epub 2007 Aug 16.
PMID: 17907813

Casimiro M, Rodriguez O, Pootrakul L, Aventian M, Lushina N, Cromelin C, Ferzli G, Johnson K, Fricke S, Diba F, Kallakury B, Ohanyerenwa C, Chen M, Ostrowski M, Hung MC, Rabbani SA, Datar R, Cote R, Pestell R, Albanese C.

ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo.

Cancer Res. 2007 May 1;67(9):4364-72.
PMID: 17483350

Hu R, Sharma SM, Bronisz A, Srinivasan R, Sankar U, Ostrowski MC.

Eos, MITF, and PU.1 recruit corepressors to osteoclast-specific genes in committed myeloid progenitors.

Mol Cell Biol. 2007 Jun;27(11):4018-27. Epub 2007 Apr 2.
PMID: 17403896

Sharma SM, Bronisz A, Hu R, Patel K, Mansky KC, Sif S, Ostrowski MC.

MITF and PU.1 recruit p38 MAPK and NFATc1 to target genes during osteoclast differentiation.

J Biol Chem. 2007 May 25;282(21):15921-9. Epub 2007 Apr 2.
PMID: 17403683

Meadows NA, Sharma SM, Faulkner GJ, Ostrowski MC, Hume DA, Cassady AI.

The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor.

J Biol Chem. 2007 Jan 19;282(3):1891-904. Epub 2006 Nov 14.
PMID: 17105730

Sharma SM, Hu R, Bronisz A, Meadows N, Lusby T, Fletcher B, Hume DA, Cassady AI, Ostrowski MC.

Genetics and genomics of osteoclast differentiation: integrating cell signaling pathways and gene networks.

Crit Rev Eukaryot Gene Expr. 2006;16(3):253-77. Review.
PMID: 17073554

Anghelina M, Moldovan L, Zabuawala T, Ostrowski MC, Moldovan NI.

A subpopulation of peritoneal macrophages form capillarylike lumens and branching patterns in vitro.

J Cell Mol Med. 2006 Jul-Sep;10(3):708-15.
PMID: 16989730

Dai B, Kim O, Xie Y, Guo Z, Xu K, Wang B, Kong X, Melamed J, Chen H, Bieberich CJ, Borowsky AD, Kung HJ, Wei G, Ostrowski MC, Brodie A, Qiu Y.

Tyrosine kinase Etk/BMX is up-regulated in human prostate cancer and its overexpression induces prostate intraepithelial neoplasia in mouse.

Cancer Res. 2006 Aug 15;66(16):8058-64.
PMID: 16912182

Chung JH, Ostrowski MC, Romigh T, Minaguchi T, Waite KA, Eng C.

The ERK1/2 pathway modulates nuclear PTEN-mediated cell cycle arrest by cyclin D1 transcriptional regulation.

Hum Mol Genet. 2006 Sep 1;15(17):2553-9. Epub 2006 Jul 18.
PMID: 16849370

Bronisz A, Sharma SM, Hu R, Godlewski J, Tzivion G, Mansky KC, Ostrowski MC.

Microphthalmia-associated transcription factor interactions with 14-3-3 modulate differentiation of committed myeloid precursors.

Mol Biol Cell. 2006 Sep;17(9):3897-906. Epub 2006 Jul 5.
PMID: 16822840

Pengal RA, Ganesan LP, Wei G, Fang H, Ostrowski MC, Tridandapani S.

Lipopolysaccharide-induced production of interleukin-10 is promoted by the serine/threonine kinase Akt.

Mol Immunol. 2006 Apr;43(10):1557-64. Epub 2005 Nov 2.
PMID: 16263172

Svensson S, Jirström K, Rydén L, Roos G, Emdin S, Ostrowski MC, Landberg G.

ERK phosphorylation is linked to VEGFR2 expression and Ets-2 phosphorylation in breast cancer and is associated with tamoxifen treatment resistance and small tumours with good prognosis.

Oncogene. 2005 Jun 23;24(27):4370-9.
PMID: 15806151

Ganesan LP, Wei G, Pengal RA, Moldovan L, Moldovan N, Ostrowski MC, Tridandapani S.

The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase.

J Biol Chem. 2004 Dec 24;279(52):54416-25. Epub 2004 Oct 12.
PMID: 15485887

Wei G, Guo J, Doseff AI, Kusewitt DF, Man AK, Oshima RG, Ostrowski MC.

Activated Ets2 is required for persistent inflammatory responses in the motheaten viable model.

J Immunol. 2004 Jul 15;173(2):1374-9.
PMID: 15240733

Sankar U, Patel K, Rosol TJ, Ostrowski MC.

RANKL coordinates cell cycle withdrawal and differentiation in osteoclasts through the cyclin-dependent kinase inhibitors p27KIP1 and p21CIP1.

J Bone Miner Res. 2004 Aug;19(8):1339-48. Epub 2004 Mar 29.
PMID: 15231022

Cao X, Wei G, Fang H, Guo J, Weinstein M, Marsh CB, Ostrowski MC, Tridandapani S.

The inositol 3-phosphatase PTEN negatively regulates Fc gamma receptor signaling, but supports Toll-like receptor 4 signaling in murine peritoneal macrophages.

J Immunol. 2004 Apr 15;172(8):4851-7.
PMID: 15067063