RECENT PUBLICATIONS 2003-2008

Hume DA, Sasmono T, Himes SR, Sharma SM, Bronisz A, Constantin M, Ostrowski MC, Ross IL.

The Ewing sarcoma protein (EWS) binds directly to the proximal elements of the macrophage-specific promoter of the CSF-1 receptor (csf1r) gene.

J Immunol. 2008 May 15;180(10):6733-42.

PMID: 18453593

Crotti TN, Sharma SM, Fleming JD, Flannery MR, Ostrowski MC, Goldring SR, McHugh KP.

PU.1 and NFATc1 mediate osteoclastic induction of the mouse beta3 integrin promoter.

J Cell Physiol. 2008 Jun;215(3):636-44.

PMID: 18288635

Trimboli AJ, Fukino K, de Bruin A, Wei G, Shen L, Tanner SM, Creasap N, Rosol TJ, Robinson ML, Eng C, Ostrowski MC, Leone G.

Direct evidence for epithelial-mesenchymal transitions in breast cancer.

Cancer Res. 2008 Feb 1;68(3):937-45.

PMID: 18245497

Sussan TE, Yang A, Li F, Ostrowski MC, Reeves RH.

Trisomy represses Apc(Min)-mediated tumours in mouse models of Down's syndrome.

Nature. 2008 Jan 3;451(7174):73-5.

PMID: 18172498 [PubMed - indexed for MEDLINE]

Opavsky R, Wang SH, Trikha P, Raval A, Huang Y, Wu YZ, Rodriguez B, Keller B, Liyanarachchi S, Wei G, Davuluri RV, Weinstein M, Felsher D, Ostrowski M, Leone G, Plass C.

CpG island methylation in a mouse model of lymphoma is driven by the genetic configuration of tumor cells.

PLoS Genet. 2007 Sep;3(9):1757-69. Epub 2007 Aug 16.

PMID: 17907813

Casimiro M, Rodriguez O, Pootrakul L, Aventian M, Lushina N, Cromelin C, Ferzli G, Johnson K, Fricke S, Diba F, Kallakury B, Ohanyerenwa C, Chen M, Ostrowski M, Hung MC, Rabbani SA, Datar R, Cote R, Pestell R, Albanese C.

ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo.

Cancer Res. 2007 May 1;67(9):4364-72.

PMID: 17483350

Hu R, Sharma SM, Bronisz A, Srinivasan R, Sankar U, Ostrowski MC.

Eos, MITF, and PU.1 recruit corepressors to osteoclast-specific genes in committed myeloid progenitors.

Mol Cell Biol. 2007 Jun;27(11):4018-27. Epub 2007 Apr 2.

PMID: 17403896

Sharma SM, Bronisz A, Hu R, Patel K, Mansky KC, Sif S, Ostrowski MC.

MITF and PU.1 recruit p38 MAPK and NFATc1 to target genes during osteoclast differentiation.

J Biol Chem. 2007 May 25;282(21):15921-9. Epub 2007 Apr 2.

PMID: 17403683

Meadows NA, Sharma SM, Faulkner GJ, Ostrowski MC, Hume DA, Cassady AI.

The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor.

J Biol Chem. 2007 Jan 19;282(3):1891-904. Epub 2006 Nov 14.

PMID: 17105730

Sharma SM, Hu R, Bronisz A, Meadows N, Lusby T, Fletcher B, Hume DA, Cassady AI, Ostrowski MC.

Genetics and genomics of osteoclast differentiation: integrating cell signaling pathways and gene networks.

Crit Rev Eukaryot Gene Expr. 2006;16(3):253-77. Review.

PMID: 17073554

Anghelina M, Moldovan L, Zabuawala T, Ostrowski MC, Moldovan NI.

A subpopulation of peritoneal macrophages form capillarylike lumens and branching patterns in vitro.

J Cell Mol Med. 2006 Jul-Sep;10(3):708-15.

PMID: 16989730

Dai B, Kim O, Xie Y, Guo Z, Xu K, Wang B, Kong X, Melamed J, Chen H, Bieberich CJ, Borowsky AD, Kung HJ, Wei G, Ostrowski MC, Brodie A, Qiu Y.

Tyrosine kinase Etk/BMX is up-regulated in human prostate cancer and its overexpression induces prostate intraepithelial neoplasia in mouse.

Cancer Res. 2006 Aug 15;66(16):8058-64.

PMID: 16912182

Chung JH, Ostrowski MC, Romigh T, Minaguchi T, Waite KA, Eng C.

The ERK1/2 pathway modulates nuclear PTEN-mediated cell cycle arrest by cyclin D1 transcriptional regulation.

Hum Mol Genet. 2006 Sep 1;15(17):2553-9. Epub 2006 Jul 18.

PMID: 16849370

Bronisz A, Sharma SM, Hu R, Godlewski J, Tzivion G, Mansky KC, Ostrowski MC.

Microphthalmia-associated transcription factor interactions with 14-3-3 modulate differentiation of committed myeloid precursors.

Mol Biol Cell. 2006 Sep;17(9):3897-906. Epub 2006 Jul 5.

PMID: 16822840

Pengal RA, Ganesan LP, Wei G, Fang H, Ostrowski MC, Tridandapani S.

Lipopolysaccharide-induced production of interleukin-10 is promoted by the serine/threonine kinase Akt.

Mol Immunol. 2006 Apr;43(10):1557-64. Epub 2005 Nov 2.

PMID: 16263172

Svensson S, Jirström K, Rydén L, Roos G, Emdin S, Ostrowski MC, Landberg G.

ERK phosphorylation is linked to VEGFR2 expression and Ets-2 phosphorylation in breast cancer and is associated with tamoxifen treatment resistance and small tumours with good prognosis.

Oncogene. 2005 Jun 23;24(27):4370-9.

PMID: 15806151

Ganesan LP, Wei G, Pengal RA, Moldovan L, Moldovan N, Ostrowski MC, Tridandapani S.

The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase.

J Biol Chem. 2004 Dec 24;279(52):54416-25. Epub 2004 Oct 12.

PMID: 15485887

Wei G, Guo J, Doseff AI, Kusewitt DF, Man AK, Oshima RG, Ostrowski MC.

Activated Ets2 is required for persistent inflammatory responses in the motheaten viable model.

J Immunol. 2004 Jul 15;173(2):1374-9.

PMID: 15240733

Sankar U, Patel K, Rosol TJ, Ostrowski MC.

RANKL coordinates cell cycle withdrawal and differentiation in osteoclasts through the cyclin-dependent kinase inhibitors p27KIP1 and p21CIP1.

J Bone Miner Res. 2004 Aug;19(8):1339-48. Epub 2004 Mar 29.

PMID: 15231022

Cao X, Wei G, Fang H, Guo J, Weinstein M, Marsh CB, Ostrowski MC, Tridandapani S.

The inositol 3-phosphatase PTEN negatively regulates Fc gamma receptor signaling, but supports Toll-like receptor 4 signaling in murine peritoneal macrophages.

J Immunol. 2004 Apr 15;172(8):4851-7.

PMID: 15067063

Cassady AI, Luchin A, Ostrowski MC, Hume DA.

Regulation of the murine TRACP gene promoter.

J Bone Miner Res. 2003 Oct;18(10):1901-4.

PMID: 14584903

Petrovic N, Bhagwat SV, Ratzan WJ, Ostrowski MC, Shapiro LH.

CD13/APN transcription is induced by RAS/MAPK-mediated phosphorylation of Ets-2 in activated endothelial cells.

J Biol Chem. 2003 Dec 5;278(49):49358-68

PMID: 14507917

Wei G, Schaffner AE, Baker KM, Mansky KC, Ostrowski MC.

Ets-2 interacts with co-repressor BS69 to repress target gene expression.

Anticancer Res. 2003 May-Jun;23(3A):2173-8.

PMID: 12894593

So H, Rho J, Jeong D, Park R, Fisher DE, Ostrowski MC, Choi Y, Kim N.

Microphthalmia transcription factor and PU.1 synergistically induce the leukocyte receptor osteoclast-associated receptor gene expression.

J Biol Chem. 2003 Jun 27;278(26):24209-16. Epub 2003 Apr 13.

PMID: 12695521 [

Baker KM, Wei G, Schaffner AE, Ostrowski MC.

Ets-2 and components of mammalian SWI/SNF form a repressor complex that negatively regulates the BRCA1 promoter.

J Biol Chem. 2003 May 16;278(20):17876-84. Epub 2003 Mar 10.

PMID: 12637547

Wu L, de Bruin A, Saavedra HI, Starovic M, Trimboli A, Yang Y, Opavska J, Wilson P, Thompson JC, Ostrowski MC, Rosol TJ, Woollett LA, Weinstein M, Cross JC, Robinson ML, Leone G.

Extra-embryonic function of Rb is essential for embryonic development and viability.

Nature. 2003 Feb 27;421(6926):942-7.

PMID: 12607001

Ghosh D, Ezashi T, Ostrowski MC, Roberts RM.

A central role for Ets-2 in the transcriptional regulation and cyclic adenosine 5'-monophosphate responsiveness of the human chorionic gonadotropin-beta subunit gene.

Mol Endocrinol. 2003 Jan;17(1):11-26.

PMID: 12511603

Sasmono RT, Oceandy D, Pollard JW, Tong W, Pavli P, Wainwright BJ, Ostrowski MC, Himes SR, Hume DA.

A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse.

Blood. 2003 Feb 1;101(3):1155-63. Epub 2002 Sep 12.

PMID: 12393599