SELECTED PUBLICATIONS

(see also PUBMED)

• Yoder, K., Sarasin, A., Kraemer, K., McIlhatton, M., Bushman, F., Fishel, R. (2006): The DNA repair genes XPB and XPD defend cells from retroviral infection. Proc. Natl. Acad. Sci. U. S. A., 103(12), 4622-7. (pdf-file)
  
  
• Meyers, M., Wagner, M.W., Mazurek, A., Schmutte, C., Fishel, R., Boothman, D.A. (2005): DNA mismatch repair-dependent response to fluoropyrimidine-generated damage. J. Biol. Chem., 280(7), 5516-26. (pdf-file)
  
  
• Lenzi, M.L., Smith, J., Snowden, T., Kim, M., Fishel, R., Poulos, B. K., Cohen, P. E. (2004): Extreme heterogeneity in the molecular events leading to the establishment of chiasmata during meiosis i in human oocytes. Am J Hum Genet., 76(1)112-27. (pdf-file)
  
  
• Snowden, T., Acharya, S., Butz, C., Berardini, M., Fishel, R. (2004): hMSH4-hMSH5 recognizes Holliday Junctions and forms a meiosis-specific sliding clamp that embraces homologous chromosomes. Mol. Cell, 15(3), 437-51. (pdf-file)
  
  
• Shim, K.S., Schmutte, C., Tombline, G., Heinen, C.D., Fishel, R. (2004): hXRCC2 enhances ADP/ATP processing and strand exchange by hRAD51. J. Biol. Chem., 279(29), 30385-94. (pdf-file)
  
  
• Acharya, S., Foster, P. L., Brooks, P., Fishel, R. (2003): The Coordinated Functions of the E. coli MutS and MutL Proteins in Mismatch Repair. Mol. Cell, 12, 233-246. (pdf-file)
  
  
• Hartmann, A., Zanardo, L., Bocker-Edmonston, T., Blaszyk, H., Dietmaier, W., Stoehr, R., Cheville, J., C., Junker, K., Wieland, W., Knuechel, R., Rueschoff, J., Hofstaedter, F., and Fishel, R. (2002) Frequent microsatellite instability in sporadic tumors of the upper urinary tract. Cancer Res., 62(23) 6796-802. (pdf-file)
  
  
• Heinen, C. D., Schmutte, C., and Fishel, R. (2002): DNA Repair and Tumorigenesis: lessons from hereditary cancer syndromes. Cancer Biology and Therapy, 1(5) 477-485. (site, pdf-file)
  
  
• Heinen, C. D., Wilson, T., Mazurek, A., Berardini, M., Butz, C. and Fishel, R. (2002): HNPCC mutations in hMSH2 result in reduced hMSH2-hMSH6 molecular switch functions. Cancer Cell, 1, 469-478. (pdf-file)
  
  
• Tombline, G. and Fishel, R. (2002): Biochemical Characterization of the human RAD51 Protein: I. ATP hydrolysis. J. Biol. Chem., 277, 14417-14425. (pdf-file)
  
  
• Tombline, G., Shim, K.-S. and Fishel, R. (2002): Biochemical Characterization of the human RAD51 Protein: II. Adenosine nucleotide binding and competition. J. Biol. Chem., 277, 14426-14433. (pdf-file)
  
  
• Tombline, G., Heinen, C. D., Shim, K.-S. and Fishel, R. (2002): Biochemical Characterization of the human RAD51 Protein: III. Modulation of DNA binding by adenosine nucleotides. J. Biol. Chem., 277, 14426-14433. (pdf-file)
  
  
• Mazurek, A., Berardini, M., and Fishel, R. (2002): Activation of human MutS homologs by 8-oxo-guanine DNA damage. J. Biol. Chem., 277, 8260-8266. (pdf-file)
  
  
• Müller, A., Fishel, R. (2002): Mismatch repair and the hereditary non-polyposis colorectal cancer syndrome (HNPCC). Cancer Invest., 20(1), 102-109.
  
  
• Müller, A., Bocker-Edmonston, T., Corao, D. A., Rose, D. G., Palazzo, J. P., Becker, H., Fry, R. D., Rueschoff, J. and Fishel, R. (2002): Exclusion of Breast Cancer as an Integral Tumor of Hereditary Nonpolyposis Colorectal Cancer. Cancer Res., 62,1014-1019. (pdf-file)
  
  
• Fishel, R. (2001): The Selection for Mismatch Repair Defects in Hereditary Nonpolyposis Colorectal Cancer. Cancer Res., 61, 7369-7374. (pdf-file)
  
  
• Slupianek, A., Schmutte, C., Tombline, G., Nieboroska-Skorska, M., Hoser, G., Nowicki, M. O., Pierce, A. J., Fishel, R. and Skorski, T. (2001): BCR/ABL Regulates Mammalian RecA Homologs Resulting in Drug Resistance. Mol.Cell, 8(4), 795-806. (pdf-file)
  
  
• Schmutte, C., Sadoff, M. M., Shim, K.-S., Acharya, S., and Fishel, R. (2001): The interaction of DNA mismatch repair proteins with human exonuclease I. J. Biol. Chem., 276, 33011-33018. (pdf-file)
  
  
• Wang, Q., Zhang, H., Guerrette, S., Chen, J., Mazurek, A., Wilson, T., Slupianek, A., Skorski, T., Fishel, R., Greene, M. (2001): Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1. Oncogene, 20, 4640-4649. (pdf-file)
  
  
• Murakumo, Y., Ogura, Y., Ishii, H., Numata, S., Ichihara, M., Croce, C. M., Fishel, R., and Takahashi, M. (2001): Interactions in the error-prone post-replication repair proteins, hREV1, hREV3, and hREV7. J. Biol. Chem., 276, 35644-35651. (pdf-file).
  
  
• Fishel, R., Acharya, S., Berardini, M., Bocker, T., Charbonmneau, N., Cranston, A., Gradia, S., Guerrette, S., Heinen, C. D., Mazurek, A., Snowden, T., Schmutte, C., Shim, K.-S., Tombline, G., Wilson, T. (2000): Signaling Mismatch Repair: The mechanics of an adenosine-nucleotide molecular switch. Cold Spring Harbor Symposia on Quantitative Biology. Vol. LXV. 217-224. (pdf-file)
  
  
• Bocker-Edmonston, T., Cuesta, K., H., Burkholderm S., Barusevicius, A., Rose, D., Kovatich, A.,J., Boman, B., Fry, R., Fishel, R., and Palazzo, J., P. (2000): Colorectal carcinomas with high microsatellite instability: defining a distinct immunologic and molecular entity with respect to prognostic markers. Human Pathology. 31(12):1506-14.
  
  
• Berardini, M., Mazurek, T., Fishel, R. (2000): The Effect of O6-methylguanine DNA adducts on the Adenosine Nucleotide Switch Functions of hMSH2-hMSH6 and hMSH2-hMSH3. J. Biol. Chem., 275, 27851-27857. (pdf-file)
  
  
• Gradia, S., Acharya, S., Fishel, R. (2000): The Role of Mismatched Nucleotides in Activating the hMSH2-hMSH6 Molecular Switch. J. Biol. Chem., 275, 3922-3930. (pdf-file)
  
  
• Murakumo, Y., Roth, T., Ishii, H., Rasio, D., Numata, S., Croce, C. M., Fishel, R. (2000): A human REV7 homolog that interacts with the Polymerase z catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2. J. Biol. Chem., 275, 4391-4397. (pdf-file)
  
  
• Schmutte, C., Fishel, R. (1999): Genomic Instability: First Step to Carcinogenesis. Anticancer Res., 19, 4665-4696.
  
  
• Cranston, A., Fishel, R. (1999): Female embryonic lethality in Msh2-Trp53 nullizygous mice is strain dependent. Mammalian Genome. 10 (10):1020-1022.
  
  
• Fishel, R. (1999): Signaling mismatch repair in cancer. Nature Medicine (N&V), 5, 1239-1241. (pdf-file)
  
  
• Wilson, T., Guerrette, S., Fishel, R. (1999): Dissociation of mismatch recognition and ATPase activity by hMSH2-hMSH3. J. Biol. Chem., 274, 21659-21664.  (pdf-file)
  
  
• Schmutte, C., Tombline, G., Sadoff, M.M., Schmutzler, R., von Deimling, A., Fishel, R. (1999): Characterization of the human Rad51 genomic locus and examination of tumors with 15q14-15 LOH. Cancer Res., 59, 4564-4569. (pdf-file)
  
  
• Bocker, T., Ruschoff, J., Fishel, R. (1999): Molecular diagnostics of cancer predisposition: hereditary non-polyposis colorectal carcinoma and mismatch repair defects. Biochimica et Biophysica Acta - Reviews on Cancer. 1423(3):O1-O10. (pdf-file)
  
  
• Bocker, T., Barusevicius, A., Snowden, T., Rasio, D., Guerrette, S., Robbins, D., Schmidt, C., Burczak, J., Croce, C. M., Copeland, T., Kovatich, A. J., Fishel, R. (1999): hMSH5: A Human MutS Homologue That Forms a Novel Heterodimer with hMSH4 and Is Expressed during Spermatogenesis. Cancer Res. 59, 816-822. (pdf-file)
  
  
• Zhang, H., Richards, B., Wilson, T., Lloyd, M., Cranston, A., Thorburn, A., Fishel, R., Meuth, M. (1999): Apoptosis Induced by Overexpression of hMSH2 or hMLH1. Cancer Res. 59, 3021-3027. (pdf-file)
  
  
• Vora, K., Tumas-Brundage, K., Lentz, V., Cranston, A., Fishel, R., Manser, T. (1999): Severe attenuation of the B-cell immune response in Msh2-deficient mice. J. Exp. Med. 189, 471-482. (pdf-file)
  
  
• Saleh, A., Srinivasula, S.,M., Acharya, S., Fishel, R., Alnemri, E.,S. (1999): Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation. J Biol Chem 274(25), 17941-17945.
  
  
• Sevignani, C., Cranston, A., Iozzo, R.V., Fishel, F., Calabretta, B. (1999): Spontaneous and mutagen-induced transformation of primary cultures of Msh2-/- p53-/- colonocytes. Cancer Res. 59, 5882-5886. (pdf-file)
  
  
• Gradia, S., Subramanian, D., Wilson, T., Acharya, S., Makhov, A., Griffith, J., Fishel, R. (1999). hMSH2-hMSH6 Forms a Hydrolysis-Independent Sliding Clamp on Mismatched DNA. Mol. Cell, 3, 255-261.  (pdf-file)
  
  
• Guerrette, S., Wilson, T., Gradia, S., Fishel, R. (1999). The interaction of the human MutL homologes in Hereditary Nonpolyposis Colon Cancer. J. Biol. Chem., 274, 6336-6341.  (pdf-file)
  
  
• Guerrette, S., Wilson, T., Gradia, S., Fishel, R. (1998). Interactions of Human hMSH2 with hMSH3 and hMSH2 with hMSH6: Examination of Mutations Found in Hereditary Nonpolyposis Colorectal Cancer. Mol Cell Biol., 18(11), 6616-6623. (pdf-file)
  
  
• Schmutte, C., Marinescu, R. C., Copeland, N. G., Jenkins, N. A., Overhauser, J., Fishel, R. (1998). Refined chromosomal localization of the mismatch repair and hereditary nonpolyposis colorectal cancer genes hMSH2 and hMSH6. Cancer Res. 58, 5023-5026. (abstract)
  
  
• Schmutte, C., Marinescu, R. C., Sadoff, M. M., Guerrette, S., Overhauser, J., Fishel, R. (1998). Human exonuclease I interacts with the mismatch repair protein hMSH2. Cancer Res. 58, 4537-4542. (abstract)
  
  
• Schmutte, C., Jones, P. A. (1998): Involvement of DNA methylation in human carcinogenesis. Biol. Chem. 379, 377-388.
  
  
• Rüschoff, J., Wallinger, S., Dietmaier, W., Bocker, T., Brockhoff, G., Hofstädter, F., Fishel, R. (1998). Aspirin suppresses the mutator phenotype associated with hereditary nonpolyposis colorectal cancer by genetic selection. Proc. Natl. Acad. Sci. USA, 95, 11301-11306.  (pdf-file)
  
  
• Fishel, R. (1998). Mismatch repair, molecular switches, and signal transduction. Genes and Development, 12(14):2096-2101, 1998. (pdf-file)
  
  
• Davis, T. W., Wilson-Van Patten, C., Meyers, M., Kunugi, K. A., Cuthill, S., Reznikoff, C., Graces, C., Boland, C. R., Kinsella, T. J., Fishel, R., Boothman, D. A. (1998): Defective Expression of the DNA Mismatch Repair Protein, MLH1, Alters G2-M Cell Cycle Checkpoint Arrest following Ionizing Radiation. Cancer Res. 58, 767-778. (abstract)
  
  
• Phung, Q.H., Winter, D.B., Cranston, A., Tarone, R.E., Bohr, V.A., Fishel, R. and Gearhart, P.J. (1998): Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient for the MSH2 mismatch repair protein. J. Exp. Med. 187, 1745-1751. (pdf-file)
  
  
• Gradia, S., Acharya, S., Fishel, R. (1997): The human mismatch recognition compex hMSH2-hMSH6 functions as a novel molecular switch. Cell, 91(7):995-1005, 1997. (pdf-file)
  
  
• Bocker, T., Diermann, J., Friedl, W., Gebert, J., Holinski Feder, E., Karner Hanusch, J., von Knebel Doeberitz, M., Koelble, K., Moeslein, G., Schackert, H. K., Wirtz, H. C., Fishel, R., Rüschoff, J. (1997). Microsatellite instability analysis: a multicenter study for reliability and quality control. Cancer Res. 57, 4739-43. (abstract)
  
  
• Cranston, A., Bocker, T., Reitmair, A., Palazzo, J., Wilson, T., Mak, T., and Fishel, R. (1997): Female embryonic lethality in mice nullizygous for both Msh2 and p53. Nature Genetics 17, 114-118.
  
  
• Dietmaier, W., Wallinger, S., Bocker, T., Kullmann, F., Fishel, R., and Rüschoff, J. (1997): Diagnostic Microsatellite Instability: Definition and Correlation with Mismatch Repair Protein Expression. Cancer Res. 57, 4749-4756. (abstract)
  
  
• Schmutte, C., Baffa, R., Veronese, L. M., Murakumo, Y., and Fishel, R. (1997): Human Thymine-DNA Glycosylase Maps at Chromosome 12q22-q24.1: a Region of High LOH in Gastric Cancer. Cancer Res. 57, 3010-3015. (abstract)
  
  
• Rasio, D., Murakumo, Y., Robbins, D., Roth, T., Silver, A., Negrini, M., Schmidt, C., Burczak, J., Fishel, R., and Croce, C. M. (1997): Characterization of the human homologue of RAD54: a gene located on chromosome 1p32 at a region of high loss of heterozygosity in breast tumors. Cancer Res. 57, 2378-83. (abstract)
  
  
• Pearson, C.,E., Ewel, A., Acharya, S., Fishel, R.,A., Sinden, R.,R. (1997): Human MSH2 binds to trinucleotide repeat DNA structures associated with neurodegenerative diseases. Human Molecular Genetics 6(7), 1117-23.
  
  
• Meyers, M., Theodosiou, M., Acharya, S., Odegaard, E., Wilson, T., Lewis, J.,E., Davis, T.,W., Vanpatten, C.,W., Fishel, R., Boothman D.,A. (1997): Cell Cycle Regulation Of the Human DNA Mismatch Repair Genes hMSH2, hMLH1, and hPMS2. Cancer Res. 57(2), 206-208.
  
  
• Fishel, R., and Wilson, T. (1997): MutS homologs in mammalian cells. Current Opinion in Genetics & Development 7, 105-13. (pdf-file)
  
  
• Mello, J. A., Acharya, S., Fishel, R., and Essigmann, J. M. (1996): The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin. Chemistry & Biology 3(7), 579-589.
  
  
• Acharya, S., Wilson, T., Gradia, S., Kane, M. F., Guerette, S., Marsischky, G., Kolodner, R., and Fishel, R. (1996): hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6. Proc. Natl. Acad. Sci. USA 93, 13629-13634. (pdf-file)
  
  
• Fishel, R. (1996): Genomic instability, mutators, and the development of cancer: is there a role for p53? Journal of the National Cancer Institute 88, 1608-9.
  
  
• Wilson, T., Ewel, A., Duguid, J. R., Eble, J. N., Lescoe, M. K., Fishel, R., and Kelley, M. R. (1995): Differential cellular expression of the human Msh2 repair enzyme in small and large intestine. Cancer Res. 55, 5146-5150.
  
  
• Fishel, R., Lescoe, M.K., Rao, M.R., Copeland, N.G., Jenkins, N.A., Garber, J., Kane, M., Kolodner, R. (1993): The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell, 75(5):1027-38.