Fishel Lab Home Page
The Fishel Laboratory is located on the 10th floor (south) of the Biological Research Tower (BRT) in room 1040. Research is focused on DNA repair and its connection to clinical problems such as infertility and cancer development. We specifically examine Mismatch Repair (MMR) and Homologous Recombination Repair (HRR) and the biophysical and genetic interactions between these two pathways. Our work demonstrated the connection of human MMR to the most common cancer susceptibility syndrome hereditary non-polyposis colorectal cancer (HNPCC; also known as Lynch syndrome). Most recent biophysical analysis includes the development of single molecule imaging technologies that allow the real-time visualization of the dynamic processes associated with protein-protein and protein-DNA interactions. Genetic analysis includes the development of pre-clinical mouse models to study chemoprevention for HNPCC patients as well as live cell single molecule analysis of DNA repair processes.
Highly motivated undergraduate students, graduate students and postdoctoral fellows interested in research are encouraged to apply for available research positions in the laboratory.